One case of malignant acanthosis nigricans associated with gastric adenocarcinoma (scirrhous type) and papilloma on the oral mucosa is presented.
The patient, 36 year old Korean male, visited S.N.U.H. complaining of sore-mouth and sore-tongue of 20 days duration. He had been affected with severe papillomatosis on the oral mucosa and with hyperkeratosis on the periorbital area, the perioral area, the neck, the axillae, the palms, the umbilical area, the inguinal area, the anogenital area and the soles which were moderately hyperpigmented with grayish to brown color.
He had not been complaining of G-I troubles except sore-mouth and sore-tongue, but he was diagnosed as stomach carcinoma by gastroendoscopy. He got an operation of extended total gastrectomy with isoperistaltic jejunal interposition.
Post-operative histopathologic examination revealed well differentiated adenocarcinoma of the stomach which had already metastasized to the neighboring lymph nodes. After operation, the papillomatosis on the oral mucosa and skin eruptions had been improved but became aggravated again one and half month after discharge.
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